Todo DSpace

Listar por tema "frontotemporal dementia"

Mostrando ítems 1-14 de 14

    • Anosognosia in Dementia: Evaluation of Perfusion Correlates Using 99mTc-HMPAO SPECT and Automated Brodmann Areas Analysis 

      Valotassiou V., Sifakis N., Tzavara C., Lykou E., Tsinia N., Kamtsadeli V., Sali D., Angelidis G., Psimadas D., Theodorou E., Tsougos I., Papageorgiou S.G., Georgoulias P., Papatriantafyllou J. (2022)
      (1) Background: Considerable inconsistency exists regarding the neural substrates of anosognosia in dementia in previous neuroimaging studies. The purpose of this study was the evaluation of anosognosia perfusion correlates ...

    • Brain Perfusion SPECT with Brodmann Areas Analysis in Differentiating Frontotemporal Dementia Subtypes 

      Valotassiou, V.; Papatriantafyllou, J.; Sifakis, N.; Tzavara, C.; Tsougos, I.; Psimadas, D.; Kapsalaki, E.; Fezoulidis, I.; Hadjigeorgiou, G.; Georgoulias, P. (2014)
      Despite the known validity of clinical diagnostic criteria, significant overlap of clinical symptoms between Frontotemporal dementia (FTD) subtypes exists in several cases, resulting in great uncertainty of the diagnostic ...

    • Cell environment shapes TDP-43 function with implications in neuronal and muscle disease 

      Šušnjar U., Škrabar N., Brown A.-L., Abbassi Y., Phatnani H., Phatnani H., Fratta P., Kwan J., Sareen D., Broach J.R., Simmons Z., Arcila-Londono X., Lee E.B., Van Deerlin V.M., Shneider N.A., Fraenkel E., Ostrow L.W., Baas F., Berry J.D., Butovsky O., Baloh R.H., Shalem O., Heiman-Patterson T., Stefanis L., Chandran S., Pal S., Smith C., Malaspina A., Hammell M.G., Patsopoulos N.A., Dubnau J., Poss M., Zhang B., Zaitlen N., Hornstein E., Miller T.M., Dardiotis E., Bowser R., Menon V., Harms M., Atassi N., Lange D.J., MacGowan D.J., McMillan C., Aronica E., Harris B., Ravits J., Crary J., Thompson L.M., Raj T., Paganoni S., Adams D.J., Babu S., Drory V., Gotkine M., Broce I., Phillips-Cremins J., Nath A., Finkbeiner S., Cox G.A., Cortese A., Cereda C., Bugiardini E., Cardani R., Meola G., Ripolone M., Moggio M., Romano M., Secrier M., Fratta P., Buratti E., NYGC ALS Consortium (2022)
      TDP-43 (TAR DNA-binding protein 43) aggregation and redistribution are recognised as a hallmark of amyotrophic lateral sclerosis and frontotemporal dementia. As TDP-43 inclusions have recently been described in the muscle ...

    • Cognitive deficits in myopathies 

      Peristeri E., Aloizou A.-M., Keramida P., Tsouris Z., Siokas V., Mentis A.-F.A., Dardiotis E. (2020)
      Myopathies represent a wide spectrum of heterogeneous diseases mainly characterized by the abnormal structure or functioning of skeletal muscle. The current paper provides a comprehensive overview of cognitive deficits ...

    • Correlation of Neuropsychiatric Symptoms in Dementia with Brain Perfu-sion: A 99mTc-SPECT-HMPAO Study with Brodmann Areas Analysis 

      Valotassiou V., Sifakis N., Tzavara C., Lykou E., Tsinia N., Kamtsadeli V., Sali D., Angelidis G., Psimadas D., Tsougos I., Papageorgiou S.G., Georgoulias P., Papatriantafyllou J. (2021)
      Background: Neuropsychiatric symptoms (NPSs) are common in dementia. Their evaluation is based on Neuropsychiatric Inventory (NPI). Neuroimaging studies have tried to elucidate the underlying neural circuits either in ...

    • Differences of apathy perfusion correlates between Alzheimer’s disease and frontotemporal dementia. A 99mTc-HMPAO SPECT study with automated Brodmann areas analysis 

      Valotassiou V., Sifakis N., Tzavara C., Lykou E., Tsinia N., Kamtsadeli V., Sali D., Angelidis G., Psimadas D., Tsougos I., Papageorgiou S.G., Georgoulias P., Papatriantafyllou J. (2022)
      Objectives: To explore differences of apathy perfusion correlates between Alzheimer’s disease (AD) and Frontotemporal dementia (FTD) using perfusion SPECT. Methods: We studied 75 FTD and 66 AD patients. We evaluated apathy ...

    • Differential diagnosis of behavioral variant and semantic variant of frontotemporal dementia using visual rating scales 

      Manouvelou S., Koutoulidis V., Tsougos I., Tolia M., Kyrgias G., Anyfantakis G., Moulopoulos L.-A., Gouliamos A., Papageorgiou S. (2020)
      Background: Frontotemporal dementia (FTD) represents the second most frequent early onset of dementia in people younger than 65 years. The main syndromes encompassed by the term FTD are behavioral variant of Frontotemporal ...

    • Eating Disorders in Frontotemporal Dementia and Alzheimer's Disease: Evaluation of Brain Perfusion Correlates Using 99mTc-HMPAO SPECT with Brodmann Areas Analysis 

      Valotassiou V., Sifakis N., Tzavara C., Lykou E., Tsinia N., Kamtsadeli V., Sali D., Angelidis G., Psimadas D., Tsougos I., Papageorgiou S.G., Georgoulias P., Papatriantafyllou J. (2021)
      Background: Eating disorders (ED) in dementia represent a significant impairment affecting patients' and caregivers' lives. In frontotemporal dementia (FTD), ED include overeating, sweet food preference, stereotypical ...

    • A novel variant in DYNC1H1 could contribute to human amyotrophic lateral sclerosis-frontotemporal dementia spectrum 

      Mentis A.-F.A., Vlachakis D., Papakonstantinou E., Zaganas I., Patrinos G.P., Chrousos G.P., Dardiotis E. (2022)
      Amyotrophic lateral sclerosis (ALS) belongs to the ALS-frontotemporal dementia (FTD) spectrum and is hallmarked by upper and lower motor neuron degeneration. Here, we present a patient with a cytoplasmic dynein 1 heavy ...

    • Patterns of cognitive impairment in neurological disease 

      Markopoulou, K. (2010)
      Cognitive impairment is present in neurodegenerative disease, usually as part of a spectrum of symptoms that includes different domains of cognitive function. While the nature of the cognitive impairment tends to be ...

    • The role of C9orf72 in neurodegenerative disorders: a systematic review, an updated meta-analysis, and the creation of an online database 

      Marogianni C., Rikos D., Provatas A., Dadouli K., Ntellas P., Tsitsi P., Patrinos G., Dardiotis E., Hadjigeorgiou G., Xiromerisiou G. (2019)
      A pathologic expansion of a noncoding GGGGCC hexanucleotide repeat of the C9orf72 gene has been strongly associated with familial amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD) cases predominantly ...

    • Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia 

      Slot R.E.R., Sikkes S.A.M., Berkhof J., Brodaty H., Buckley R., Cavedo E., Dardiotis E., Guillo-Benarous F., Hampel H., Kochan N.A., Lista S., Luck T., Maruff P., Molinuevo J.L., Kornhuber J., Reisberg B., Riedel-Heller S.G., Risacher S.L., Roehr S., Sachdev P.S., Scarmeas N., Scheltens P., Shulman M.B., Saykin A.J., Verfaillie S.C.J., Visser P.J., Vos S.J.B., Wagner M., Wolfsgruber S., Jessen F., Boada M., de Deyn P.P., Jones R., Frisoni G., Spiru L., Nobili F., Freund-Levi Y., Soininen H., Verhey F., Wallin Å.K., Touchon J., Rikkert M.O., Rigaud A.-S., Bullock R., Tsolaki M., Vellas B., Wilcock G., Froelich L., Bakardjian H., Benali H., Bertin H., Bonheur J., Boukadida L., Boukerrou N., Chiesa P., Colliot O., Dubois B., Dubois M., Epelbaum S., Gagliardi G., Genthon R., Habert M.-O., Houot M., Kas A., Lamari F., Levy M., Metzinger C., Mochel F., Nyasse F., Poisson C., Potier M.-C., Revillon M., Santos A., Andrade K.S., Sole M., Surtee M., Thiebaud de Schotten M., Vergallo A., Younsi N., van der Flier W.M., Alzheimer's Disease Neuroimaging Initiative, DESCRIPA working group, INSIGHT-preAD study group, SCD-I working group (2019)
      Introduction: In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non-AD dementia and (2) determinants ...

    • TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A 

      Brown A.-L., Wilkins O.G., Keuss M.J., Hill S.E., Zanovello M., Lee W.C., Bampton A., Lee F.C.Y., Masino L., Qi Y.A., Bryce-Smith S., Gatt A., Hallegger M., Fagegaltier D., Phatnani H., Phatnani H., Kwan J., Sareen D., Broach J.R., Simmons Z., Arcila-Londono X., Lee E.B., Van Deerlin V.M., Shneider N.A., Fraenkel E., Ostrow L.W., Baas F., Zaitlen N., Berry J.D., Malaspina A., Fratta P., Cox G.A., Thompson L.M., Finkbeiner S., Dardiotis E., Miller T.M., Chandran S., Pal S., Hornstein E., MacGowan D.J., Heiman-Patterson T., Hammell M.G., Patsopoulos N.A., Butovsky O., Dubnau J., Nath A., Bowser R., Harms M., Aronica E., Poss M., Phillips-Cremins J., Crary J., Atassi N., Lange D.J., Adams D.J., Stefanis L., Gotkine M., Baloh R.H., Babu S., Raj T., Paganoni S., Shalem O., Smith C., Zhang B., Harris B., Broce I., Drory V., Ravits J., McMillan C., Menon V., Wu L., Altschuler S., Lerner Y., Sattler R., Van Keuren-Jensen K., Rozenblatt-Rosen O., Lindblad-Toh K., Nicholson K., Gregersen P., Lee J.-H., Kokos S., Muljo S., Newcombe J., Gustavsson E.K., Seddighi S., Reyes J.F., Coon S.L., Ramos D., Schiavo G., Fisher E.M.C., Raj T., Secrier M., Lashley T., Ule J., Buratti E., Humphrey J., Ward M.E., Fratta P., NYGC ALS Consortium (2022)
      Variants of UNC13A, a critical gene for synapse function, increase the risk of amyotrophic lateral sclerosis and frontotemporal dementia1–3, two related neurodegenerative diseases defined by mislocalization of the RNA-binding ...

    • Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism 

      Conlon E.G., Fagegaltier D., Agius P., Davis-Porada J., Gregory J., Hubbard I., Kang K., Kim D., Phatnani H., Shneider N.A., Manley J.L., Kwan J., Sareen D., Broach J.R., Simmons Z., Arcila-Londono X., Lee E.B., Van Deerlin V.M., Fraenkel E., Ostrow L.W., Baas F., Zaitlen N., Berry J.D., Malaspina A., Fratta P., Cox G.A., Thompson L.M., Finkbeiner S., Dardiotis E., Miller T.M., Chandran S., Pal S., Hornstein E., Macgowan D.J., Heiman-Patterson T., Hammell M.G., Patsopoulos N.A., Dubnau J., Nath A., The New York Genome Center ALS Consortium (2018)
      Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) represent two ends of a disease spectrum with shared clinical, genetic and pathological features. These include near ubiquitous pathological inclusions ...